Study on the Correlation between CGM Monitoring Blood Glucose Fluctuation and SMBG Blood Glucose Fluctuation Indexes in Type 2 Diabetes Patients
Objective:To study the correlation between the amplitude of blood glucose fluctuations measured by continuous glucose monitoring(CGM)and the self-monitoring of blood glucose(SMBG)blood glucose fluctuation indexes in patients with type 2 diabetes.Methods:82 cases type 2 diabetes patients in our hospital from June 2022 to June 2023 were selected in the study.All the patients received SMBG at 7 time points(before meals,2 h after meals,and before sleep)and CGM for 48-72 h.Blood glucose fluctuation indica-tors such as coefficient of variation(CV),largest amplitude of glycemic excursions(LAGE),mean amplitude of glucose excursion1(MAGE1,calculated by SMBG),standard deviation of blood glucose(SDBG),and postprandial glucose excursion(PPGE)were calcu-lated based on 7 time point SMBG data.Simple linear regression analysis,Spearman rank correlation analysis,and multiple stepwise regression analysis were used to analyze the correlation between MAGE obtained through CGM and CV,LAGE,MAGE1,SDBG,and PPGE calculated through SMBG.Results:Multiple stepwise regression analysis was conducted using MAGE obtained through CGM as the dependent variable and CV,LAGE,MAGE1,SDBG,and PPGE calculated through SMBG as the independent variables.The results showed that MAGE obtained through CGM was related to CV,LAGE,MAGE1,SDBG,and PPGE calculated through SMBG(P<0.05).The Spearman rank correlation analysis results showed that the MAGE obtained through CGM was positively correlated with CV,LAGE,MAGE1,SDBG,and PPGE calculated through SMBG(P<0.05).Conclusion:The MAGE obtained through CGM monitoring is corre-lated with the blood glucose fluctuation indicators such as CV,LAGE,MAGE1,SDBG,PPGEcalculated through SMBG in type 2 diabe-tes patients.The blood glucose fluctuation indicators calculated through SMBG can be used to reflect the daily blood glucose fluctuation of type 2 diabetes patients.
Type 2 diabetesContinuous glucose monitoringSelf-monitoring blood glucoseBlood glucose fluctuationsCorrelation
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