首页|中西医治疗儿童腺样体肥大及对体内白介素影响的研究进展

中西医治疗儿童腺样体肥大及对体内白介素影响的研究进展

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儿童腺样体肥大(adenoidal hypertrophy,AH)是一种儿科常见的疾病,其发病过程中涉及多种细胞因子的参与,特别是白细胞介素(interleukin,IL)在其中起着关键作用.研究表明,IL1~18参与了儿童AH的不同病理阶段,并对气道炎症具有双向调节作用.中医方面,中药通过调节IL等细胞因子的表达,从而调节机体的炎症状态或免疫功能.西医方面,抗组胺药、糖皮质激素和白三烯受体阻断剂等药物影响IL等细胞因子的表达和活性进而治疗AH.此外,手术方法如腺样体切除术、吸切术和等离子消融术也对IL水平有不同程度的影响.同时,中西药联合应用对体内IL有影响,显示出一定的治疗效果.体内IL水平的变化在儿童AH及其并发症的发病机制中发挥了一定作用,成为治疗儿童AH及其并发症的关键性进展领域.未来,应进一步探讨IL与其他信号通路的交互机制、IL基因多态性等与儿童AH的关系及相互影响,探讨IL在儿童AH治疗中的单独或联合应用策略,为儿童AH的治疗提供更多科学依据和研究思路.
Research Progress on Treatment of Children Adenoidal Hypertrophy with Traditional Chinese and Western Medicine and Its Effect on Levels of Interleukins
Adenoidal hypertrophy(AH)is a common pediatric disease,involving the participation of multiple cytokines during its pathogenesis,particularly the crucial role played by interleukin(IL).Studies have shown that IL1 to IL18 are involved in different patho-logical stages of AH in children and have bidirectional regulatory effects on airway inflammation.In traditional Chinese medicine,Chi-nese herbal medicine regulates the inflammatory state or immune function of the body by modulating the expression of cytokines such as IL.In Western medicine,drugs such as antihistamines,glucocorticoids,and leukotriene receptor antagonists affect the expression and activity of cytokines including IL,thus treating AH.Additionally,surgical methods such as adenoidectomy,suction curettage,and plasma ablation also have varying degrees of impact on IL levels.Meanwhile,the combined application of traditional Chinese and West-ern medicine also affects IL levels in the body,demonstrating a certain therapeutic effect.The changes of IL levels in the body play a cer-tain role in the pathogenesis of AH and its complications in children,and become a key area of progress in the treatment of AH and its complications in children.In the future,further exploration of the interaction mechanism between IL and other signaling pathways,the relationship and impact of IL gene polymorphisms with AH in children,as well as strategies for the independent or combined application of IL in the treatment of AH in children,are needed to provide more scientific evidence and research ideas for the treatment of AH in children.

Adenoidal hypertrophyInterleukinChildrenResearch progress

孙会婷、庄玲伶

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长春中医药大学,吉林 长春 130117

吉林省中医药科学院第一临床医院,吉林 长春 130033

腺样体肥大 白细胞介素 儿童 研究进展

2022年度吉林省中医药科技项目

2022061

2024

中国医药导刊
国家食品药品监督管理局信息中心

中国医药导刊

影响因子:1.408
ISSN:1009-0959
年,卷(期):2024.26(5)