The Value of Titanium Clamp Labeling Under Gastroscope in Target Delineation of Radical Intensity Modulated Radiotherapy for Patients with Inoperable Locally Advanced Esophageal Cancer
Objective:To evaluate the value of titanium clamp labeling under gastroscopy in target delineation of radical intensity modulated radiotherapy (IMRT) in patients with inoperable locally advanced esophageal cancer. Methods:A total of 150 patients with inoperable locally advanced esophageal cancer who received radical intensity modulated radiotherapy in our hospital from January 2021 to December 2021 were selected as the research objects. They were divided into the control group 1,control group 2 and observation group according to random number table method. Esophageal barium meal imaging was performed before radiotherapy in control group 1,and CT scanning was performed in control group 2 before radiotherapy. The observation group was labeled with titanium clamp under gastro-scope before radiotherapy,and the delineation effect of target areas was compared among the three groups. The short-term efficacy after 6 weeks of radiotherapy was evaluated,adverse reactions were observed,and the long-term prognosis was analyzed by recording progression-free survival (PFS) and overall survival (OS) for evaluation. Results:There were statistically significant differences in lesion length,GTV,and CTV among the three groups of patients (P<0.05). The lesion length,GTV,and CTV of the observation group and the control group 2 were higher than those of the control group 1 (P<0.05). There was no statistically significant difference in lesion length and GTV between the observation group and the control group 2 (P>0.05),but the CTV of the observation group was lower than that of the control group 2 (P<0.05). The total effective rate of the three groups of patients was compared,and the difference was statisti-cally significant (P<0.05). The total effective rate of the observation group was 96.00％,which was higher than that of the control group 1 (84.00％) (P<0.05). There was no statistically significant difference in adverse reactions among the three groups of patients (P>0.05). Follow up until June 2024,the control group 1 patients had PFS of 1-17 months (9 months) and OS of 2-31 months (15 months),the PFS of the control group 2 patients was 1-16 months (10 months) and OS was 2-34 months (15 months),and the PFS and OS of the observation group patients were 3-20 months (12 months) and 3-44 months (22 months),respectively. Kaplan-Meier sur-vival curves showed that the PFS and OS of the observation group patients were longer than those of the control group 1 and control group 2 patients (P<0.05).Conclusion:Titanium clamp labeling under gastroscope is helpful to accurately delineate the target area of patients with unresectable locally advanced esophageal cancer,which can avoid the influence of inadequate radiotherapy dose after esophageal barium meal imaging and increased radiation dose of normal organs after CT scan localization,and can obtain reliable short-term efficacy and good long-term prognosis.
Local late stageEsophageal cancerGastroscopeTitanium clampIntensity modulated radiotherapyTarget delineation
万方数据
维普
