首页|肠道菌群与天然产物的相互作用研究进展

肠道菌群与天然产物的相互作用研究进展

扫码查看
大量研究表明天然产物对肠道菌群具有多种生物活性,可能影响肠道菌群组成、菌群代谢物含量及肠道黏膜屏障完整性等,同时肠道菌群产生的多种酶又能影响天然产物活性成分的生物利用度以及药理毒理活性。两者相互作用对宿主的健康和疾病治疗至关重要。本文按照天然产物活性成分的结构类型归纳了天然产物与肠道菌群的相互作用的分子机制,为进一步研究天然产物如何通过调控肠道菌群进而发挥治疗疾病的作用提供参考依据。
A large number of studies have shown that natural products possess a wide variety of biological activities on the intestinal microflora,which may affect the composition of the intestinal microflora,the content of metabolites of the intestinal microflora and the integrity of the intestinal mucosal barrier.At the same time,the intestinal microflora produces a variety of enzymes,which can affect the bioavailability,pharmacological and toxicological activities of active components of natural products.The interaction between natural products and the intestinal microflora is crucial for host health and disease treatment.This review summarizes the molecular mechanisms of the interaction between natural products and the intestinal microflora according to the structural types of active ingredients of natural products,providing a reference for further research on how natural products play a role in treating diseases by regulating gut microbiota.

intestinal microfloranatural productsinteractionsmolecular mechanisms

丁劲文、林媛、蒋建东

展开 >

100050 北京,中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室

肠道菌群 天然产物 相互作用 分子机制

中国医学科学院医学与健康科技创新工程中国医学科学院医学与健康科技创新工程

2021-I2M-1-0262022-I2M-2-002

2024

中国医药生物技术
中国医药生物技术协会

中国医药生物技术

CSTPCD
影响因子:0.368
ISSN:1673-713X
年,卷(期):2024.19(1)
  • 51