摘要
黄杉素是一种二氢黄酮醇类活性天然产物,具有多种显著的药理活性,包括抗氧化,保护心血管和肝脏等,广泛应用于美容、保健、食品和医疗产业.黄杉素目前主要通过植物提取,产量不足限制了其广泛应用,而生物合成方法研究的快速发展有望为其高效获取提供新契机.本文综述了黄杉素的结构性质、生物合成途径、药理作用以及生产方式,并对未来合成生物学技术在黄杉素生产中的应用进行展望.
Abstract
Taxifolin,an active natural dihydroflavonol,exhibits a range of notable pharmacological activities,including antioxidant properties and cardiovascular and hepatic protection effects.Widely utilized in the cosmetic,health,food,and medical industries,taxifolin plays a crucial role in the treatment of liver and cardiovascular diseases.While traditionally extracted from plants,limited yields hinder its widespread application.Recent advancements in biosynthetic methods present new opportunities for efficient production.This review delves into the structural characteristics,biosynthetic pathways,pharmacological effects,and production techniques of taxifolin,while also exploring the potential integration of synthetic biology technologies to enhance taxifolin production in the future.
基金项目
国家自然科学基金(32170274)
国家自然科学基金(82225047)
国家重点研发计划(2022YFC3501703)
国家重点研发计划(2023YFC3504800)
上海市"科技创新行动计划"启明星项目(23QA1411400)
NETL
NSTL
万方数据