Cancer stem cells are a subset of cells with self-renewal,replication and differentiation abilities,accounting for a small proportion in tumor tissue.However,they can influence the process of tumor occurrence,development,and recurrence,playing a crucial role in tumor heterogeneity.Therefore,in order to completely cure tumors,treatment targeting cancer stem cells must be considered.Cancer stem cells can maintain their own stem cell characteristics through different signaling pathways,gene regulation,and cell interactions,while also promoting tumor cell proliferation,invasion,and metastasis,so it becomes an important target in tumor therapy.The microenvironment of cancer stem cells has a significant impact on tumor occurrence and development,including recurrence,drug resistance,metastasis and other events.In summary,starting from tumor stem cells and describing the relevant signaling pathways of tumor stem cells,this paper reviews the relevant therapies targeting cancer stem cells,such as immunotherapy,pro-differentiation therapy,and miRNA therapy,in order to provide new ideas for tumor therapy.
万方数据
维普
