Copper is an essential micronutrient for organisms.It serves as an important catalytic cofactor in redox reactions and is the basic structural component of many crucial enzymes.Additionally,elevated copper ions have been observed in various malignant tumors,where they play a role in promoting tumor progression.Cuproptosis is a newly identified regulatory cell death mechanism that occurs when copper ions bind to fatty acylated proteins in the tricarboxylic acid cycle during mitochondrial respiration.This binding leads to protein aggregation,down-regulation of iron-sulfur tuftin expression,and induction of protein toxic stress,ultimately resulting in cell death.Genes associated with cuproptosis may aid in predicting prognosis and serve as a new therapeutic target in the diagnosis and treatment of breast cancer.This article reviews the progress of cuproptosis and its role in breast cancer.
关键词
铜死亡/铜稳态/细胞死亡/乳腺癌
Key words
cuproptosis/copper homeostasis/cell death/breast cancer
维普
万方数据