Rheumatoid arthritis is a complex autoimmune disease with no definitive treatment currently available.Long-term use of antirheumatic drugs can lead to numerous side effects.RNA interference technology involves the targeted degradation of specific gene mRNA using exogenous or endogenous double-stranded RNA,resulting in gene silencing.This technology offers high efficiency,specificity and low toxicity,making it highly promising in biomedicine.Small interfering RNAs(siRNAs),crucial effectors of RNA interference,show significant potential in the treatment of rheumatoid arthritis.This article provides an overview of the recent advancements in siRNA delivery system for the treatment of rheumatoid arthritis,highlighting the advantages of siRNA nanodelivery systems in this context and discussing potential future directions in siRNA delivery research.
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