微流控技术在脂质纳米载体制备中的应用研究进展
吕芊芊 1魏淑洁 1郝锦涛 1闫梦 1安青青 1何朝星 1向柏1
作者信息
- 1. 050017 石家庄,河北医科大学药学院
- 折叠
摘要
脂质纳米载体是递送各种药物的重要工具,尽管在过去数年间得到了发展,但却仍然受到制造工艺的限制.例如,传统方法生产的脂质纳米载体存在粒径不均一、产量低以及批次间差异大等诸多局限性.为了克服这些阻碍,微流控技术在脂质纳米载体制备中的应用逐渐增多,其能够以更高的产量获得粒径均一、性能可控的脂质纳米载体.本文综述了微流控技术在脂质体、脂质纳米颗粒等纳米载体制备中的优势,并且总结了基于微流控技术的脂质纳米载体用于小分子、寡核苷酸药物递送的最新研究进展.
Abstract
Lipid nanocarriers play a crucial role in the delivery of a diverse range of drugs,but their manufacturing process has posed challenges despite advancements in recent years.For example,lipid nanocarriers produced by traditional methods have many limitations such as inconsistent particle size,low yield,and large batch-to-batch variations.To address these limitations,there is a growing interest in utilizing microfluidic technology for the preparation of lipid nanocarriers.Microfluidic techniques offer the ability to create lipid nanocarriers with uniform particle sizes and customizable properties,leading to higher yields.This paper provides an overview of the benefits of using microfluidic technology in the production of nanocarriers like liposomes and lipid nanoparticles,and highlights recent research progress advances in utilizing microfluidic-based lipid nanocarriers for the delivery of small molecules and oligonucleotide drugs.
关键词
微流控/脂质体/脂质纳米颗粒/药物递送/纳米载体Key words
microfluidic/liposomes/lipid nanoparticles/drug delivery/nanocarriers引用本文复制引用
基金项目
国家自然科学基金(81973251)
河北省引进留学人员资助项目(C20230351)
石家庄市基础研究计划项目-重点项目(241791397A)
出版年
2024
NETL
NSTL
万方数据