Lipid nanocarriers play a crucial role in the delivery of a diverse range of drugs,but their manufacturing process has posed challenges despite advancements in recent years.For example,lipid nanocarriers produced by traditional methods have many limitations such as inconsistent particle size,low yield,and large batch-to-batch variations.To address these limitations,there is a growing interest in utilizing microfluidic technology for the preparation of lipid nanocarriers.Microfluidic techniques offer the ability to create lipid nanocarriers with uniform particle sizes and customizable properties,leading to higher yields.This paper provides an overview of the benefits of using microfluidic technology in the production of nanocarriers like liposomes and lipid nanoparticles,and highlights recent research progress advances in utilizing microfluidic-based lipid nanocarriers for the delivery of small molecules and oligonucleotide drugs.
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