Drug target is a key in drug discovery. Although cells have over 30000 proteins,for particular cellular function only few of the proteins are critical. The biological role of the critical proteins could be described as "head goose effect",and these molecules could be called "head goose molecules (HGMs)". We assume that under the support from intra-or extra-cellular circumstances the HGMs could be regulated by drugs,then release instructive signals (for instance,protein modification) to other proteins. Through proper cooperation of the HGMs with other protein molecules the disease cell could be reprogrammed,yielding safe and therapeutic effects. Therefore,HGMs might be the best drug targets. Here,we show good HGM examples in energy metabolism,and drugs that target the metabolic HGMs are quite successful in clinic. We hope the thought interest for those working on drug target discovery.
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