摘要
黄酮是一类广泛存在于植物中的次生代谢产物,具有抗炎、抗癌、抗心血管疾病、抗糖尿病、抗衰老和辐射防护等多种药理活性.目前,黄酮类化合物生产主要依赖于植物提取和化学合成,但难以满足市场需求.因此,采取微生物合成天然产物为其大规模生产提供了新的方法.本文综述了在黄酮类化合物生产中,构建微生物细胞工厂的策略,并整理了近些年通过合成生物学生产黄酮类化合物的相关实例,为黄酮类化合物的合成生物学研究提供参考.
Abstract
Flavonoids,widely present secondary metabolites found in plants,exhibit a spectrum of pharmacological activities,including anti-inflammatory,anti-cancer,anti-cardiovascular disease,anti-diabetes,anti-aging and radiation protection properties. Currently,the production of flavonoids primarily relies on plant extraction and chemical synthesis,which may not be able to meet the market demand. As a result,microbial synthesis of natural products has emerged as a novel approach for achieving their large-scale production. In the paper,we review the strategies for constructing microbial cell factories in flavonoid production and compile relevant examples of flavonoid production through synthetic biology in recent years,providing a valuable reference for synthetic biology research on flavonoids.
维普
万方数据