Objective To explore the latent profiles of mindfulness levels among chronic HBV infected patients,and to analyze the population characteristics and influencing factors of different profiles.Methods From April 2020 to January 2021,chronic HBV infected patients from an infectious disease hospital in Shandong Province were selected by successive sampling method and investigated using a general information questionnaire,the Mindful Attention Awareness Scale and the Social Support Rating Scale.The latent profiles were analyzed using the Mindful Attention Awareness Scale score as an exogenous indicator,and the influencing factors of different profiles of mindfulness were explored by univariate analysis and binary logistic regression.Re-sults Positive thinking level of chronic HBV-infected patients could be categorized into low positive thinking level group(39.68%)and medium-high positive thinking level group(60.32%).Univariate analysis of variance showed that gender,self-assessment of health status,satisfaction with support,severity of discrimination,and social support(objective support,subjec-tive support,and utilization of support)were predictive of the 2 potential categories of positivity level in chronically HBV-infected patients with statistically significant differences(P<0.05).Binary logistic regression showed that gender(OR=0.499,P=0.017),self-assessment of health status(OR=1.789,P=0.001),severity of discrimination(OR=0.718,P=0.025),and subjective support(OR=1.066,P=0.016)would have an effect on the latent profiles of the level of positive thinking among people with chronic HBV infection.Conclusion Heterogeneity exists in the level of mindfulness among chronic HBV infected pa-tients,and healthcare workers can identify population characteristics and influencing factors of different profiles by categorizing chronic HBV infected patients to provide more precise intervention programs to improve their mindfulness level.