Objective To understand the trend of nosocomial infection prevalence in China,and to predict the nosoco-mial infection prevalence in hospitals of different scales in China with the gray GM(1,1)model,so as to provide data support and new ideas for prevention and control of nosocomial infection.Methods Descriptive epidemiological method was used to ana-lyze the trend of nosocomial infection prevalence in China.The grey GM(1,1)model was constructed with data on nosocomial infection prevalence in China from 2008 to 2016,and the model was validated with data from 2018 to 2020.The constructed grey GM(1,1)model was used to predict the prevalence of nosocomial infection in China from 2022 to 2024.Results The preva-lence of nosocomial infection in China showed a downward trend.The prevalence of nosocomial infection increased with the in-crease of hospital scales.The grey GM(1,1)model for the prevalence of nosocomial infection has good accuracy and high fitting effect.In 2024,the prevalence of nosocomial infection in China,in hospitals with<300 beds,in hospitals with 300-599 beds,in hospitals with 600-899 beds,and in hospitals with≥ 900 beds can be reduced to 1.00%,0.49%,0.90%,1.13%,and 2.05%,respectively.Conclusion The prevention and control effect of nosocomial infection in China is obvious,and the grey GM(1,1)model has a good prediction effect on the prevalence of nosocomial infection in China.