2型糖尿病患者急性冠心病事件发病风险的回顾性队列研究
Retrospective cohort study on risk of acute coronary events in patients with type 2 diabetes mellitus
樊丽辉 1姜雪霞 1郑宇航 1叶振淼 1罗永园1
作者信息
- 1. 温州市疾病预防控制中心慢病所,325001浙江 温州
- 折叠
摘要
目的 分析2型糖尿病患者急性冠心病事件的发病风险,为糖尿病患者管理提供依据.方法 基于温州市慢性病协同管理系统数据进行回顾性队列研究,277 205例2010-2020年诊断的新发2型糖尿病患者纳入分析,通过身份证号与急性冠心病事件监测库和死亡监测数据库进行匹配,获得冠心病发病和死亡信息.采用Cox风险回归模型分析糖尿病患者确诊时并发症情况与急性冠心病事件发病风险的关联.结果 随访期间共有3 241例2型糖尿病患者发生急性冠心病事件,冠心病发病率为1 169.17/10万.1 083名糖尿病患者因冠心病死亡,病死率390.69/10万.以糖尿病患者确诊时无并发症为参照,1个并发症和2个及以上者冠心病发病风险HR分别为1.382(95％CI:1.266～1.508)和1.661(95％CI:1.221～2.259).结论 2型糖尿病患者急性冠心病事件的发病和死亡风险较高,在患者管理中应加强干预,积极防治并发症发生.
Abstract
Objective To analyze the risk of acute coronary events in patients with type 2 diabetes mellitus,and to pro-vide basis for the management of patients.Methods Based on the data of Wenzhou chronic disease collaborative management system,a retrospective cohort study was conducted.A total of 277 205 newly diagnosed type 2 diabetes mellitus patients from 2010 to 2020 were included in the analysis.The incidence and death information were obtained by matching the ID number with the data of acute coronary events and deaths.COX regression model was used to analyze the relationship between the complica-tions of diabetes patients at the time of diagnosis and the risk of acute coronary events.Results During the follow-up period,acute coronary events occurred in 3 241 cases,and the incidence rate of coronary heart disease was 1 169.17/100 000;1 083 di-abetes patients died from coronary heart disease,with a fatality rate of 390.69/100 000.Taking the patients diagnosed without complications as the reference,the HR of acute coronary disease in patients with one complication and two or more was 1.382(95％CI:1.266-1.508)and 1.661(95％CI:1.221-2.259)respectively.Conclusion Type 2 diabetes patients have a high risk of morbidity and mortality from acute coronary events,so intervention should be strengthened in patient management to ac-tively prevent and treat complications.
关键词
2型糖尿病/冠心病/队列研究Key words
type 2 diabetes mellitus/acute coronary event/cohort study引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据