Objective To study the medical records of patients with malignant tumors in a tertiary hospital,to grasp the composition and change trend of the main malignant tumor diseases,and to provide scientific reference for the prevention and treatment of malignant tumors in the local area.Methods Data of the first page of medical records of malignant tumor patients in a hospital from 2017 to 2021 were collected and retrospectively analyzed in terms of disease composition,sequence structure,age and gender distribution of patients with malignant tumors in the hospital.Results Totally 19 198 patients with malignant tumor were admitted,and the gender ratio was 1.3∶1.The proportion of hospitalized patients aged 50-69 was the highest(50.66%),and the mortality rate of malignant tumor was 4.96%.The top 5 malignant tumors were lung cancer,liver cancer,nasopharynx cancer,breast cancer,and colon cancer.The average medical cost of malignant tumor patients was 23 711.55 yuan,the average medicine cost was 4 851.93 yuan and the average hospitalization days were 13.03 days.Conclusion It should be aimed at high-risk groups and common types of malignant tumors.It is necessary to formulate comprehensive prevention and treatment measures for local population with malignant tumors over 50 years old,carry out cancer screening for early diagnosis and treatment,and strengthen control over medical expenses.