Objective To investigate the composition and change of respiratory diseases in a tertiary hospital in Hainan Province,and to provide reference for scientific prevention and control of diseases,dynamic allocation of medical resources and discipline development planning.Methods The home page information of respiratory patients in a tertiary hospital in Hainan Province from 2019 to 2023 was selected,and the diseases were classified according to ICD-10 classification standard,and the gender,age,disease distribution and seasonal distribution of inpatients were retrospectively analyzed.Results A total of 25 003 inpatients were hospitalized from 2019 to 2023,with a male/female ratio of 1.60∶1;the majority of inpatients were middle-aged and the elderly,the least were children and adolescents,but the proportion of both increased year by year;the most patients were hospitalized in winter and the least in autumn;the rank change of inpatient diseases was statistically significant(P<0.001),in-fluenza and pneumonia always ranked first,chronic lower respiratory diseases showed a downward trend year by year,and other diseases of respiratory system showed an upward trend year by year;the inpatient diseases were mainly influenza and pneumonia(48.2%),the proportion of inpatient diseases in infants(0-3 years old)was the highest(81.9%),and the proportion of inpa-tient diseases in adolescents(7-17 years old)was the lowest(37.3%).Conclusion It is necessary to strengthen health educa-tion,improve disease cognition,dynamically allocate medical resources according to the distribution of diseases,and strengthen the discipline construction and special disease management of pediatrics,geriatrics and respiratory medicine.