Objective To analyze the composition and drug resistance of pathogens in patients with bloodstream infection in a comprehensive hospital,and to provide a basis for the early empirical application of antibiotics.Methods The clinical char-acteristics of patients with bloodstream infection in a tertiary comprehensive hospital in Zibo City from January 2017 to December 2022 were analyzed.Positive strains isolated from patinets with bloodstream infection were collected for bacterial identification,drug sensitivity testing,and drug resistance analysis.Results There were 2 476 patients with positive blood cultures in the hos-pital,and 3 034 non-duplicate strains were isolated from 2017 to 2022.Among them,there were 1 390 cases of gram negative bacteria(45.81％),1 529 cases of gram positive bacteria(50.40％),26 cases of fungi(0.86％),and 89 cases of anaerobic bacteria(2.93％).Compared with 2017 to 2019,from 2020 to 2022,the resistance rates of Escherichia coli to ciprofloxacin and levofloxacin increased from 42.78％& 40.68％to 50.54％& 50.00％,respectively(P＜0.05).The resistance rate of Pseudomonas aeruginosa to cefepime and amtronam increased from 0.00％and 39.13％to 10.71％and 53.57％,respectively(P＜0.05).And the resistance rates of Staphylococcus aureus to clindamycin and erythromycin decreased from 61.54％&79.49％to 22.45％& 53.06％,respectively(P＜0.05).Analysis of clinical characteristics of patients with bloodstream infec-tion showed that there were significant differences in age and gender between the two groups of 2017 to 2019 and 2020 to 2022(P＜0.05).Conclusion The composition of pathogens in bloodstream infection shows an increasing trend in gram negative bacteria and fungi,while gram positive bacteria and anaerobic bacteria show a decreasing trend.Some pathogenic bacteria have significantly increased resistance to certain antibiotics,which should be paid more attention in clinics.
bloodstream infectioncomprehensive hospitaldistribution of pathogenic bacteriadrug resistancemulti-drug resistant bacteria
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