安律胶囊对豚鼠心室肌细胞钠离子通道的影响
Effect of Anlv Capsule on sodium ion channels in ventricular myocytes of guinea pig
徐惠梅 1姜小刚 1张文杰 2李雁 1任家毅1
作者信息
- 1. 黑龙江省中医研究院心血管科,哈尔滨,150036
- 2. 吉林大学基础医学院生理教研室,长春,130021
- 折叠
摘要
目的:通过观察安律胶囊对豚鼠心室肌细胞钠电流(INa)的影响,以探讨其抗早搏的作用机制.方法:采用膜片钳全细胞记录技术记录了安律胶囊对单个豚鼠心室肌细胞钠电流的影响.结果:安律胶囊可剂量依赖性的阻滞钠电流且具有一定的使用依赖性和时间依赖性.结论:安律胶囊对钠电流的阻滞作用是其抗早搏的作用机制之一.
Abstract
Objective: To observe the effect of Aalv Capsule on sodium current in guinea pig ventricular myocytes (INa) for exploring the mechanism of its anti-premature beats. Methods: Whole-cell patch-clamp recording technique was used to record the Aalv Capsule for a single cell of sodium currents in guinea pig ventricular myocytes. Results: There was dose-dependent of Aalv Capsule in block of sodium currents and had a certain amount of use-dependent and time-dependent. Conclusion: The role of Aalv Capsule in blocking sodium current block was one of the mechaulsms of its in bearing premature.
关键词
心室肌细胞/钠离子通道电流/膜片钳全细胞记录技术/早搏/安律胶囊Key words
The ANLV capsules/ventricular myocytes/sodium current/The whole-cell patch-clamp recording technique/Premature beats引用本文复制引用
出版年
2010
国家科技期刊平台
NSTL
维普
万方数据