Objective: To isolate and identify the composition from the whole plant of Saxifraga tangutica, which has been used as traditional herb medicine in the treatment of some diseases. Methods: These compounds were isolated by column chromatography and their structures were elucidated through spectroscopic analysis (NMR and MS). Results: Six compounds were isolated and identified as: quercetin (I), quercetin-3-O-β-D-glucopyranoside (H), quercetin-3-O-β-D-glucopyranoside (ID), quercetin-3-O- β -D-galactoside-7-O- β -D-glucoside (IV), β -sitosterol (V), dausterol (VI). Conclusion: All these compounds were obtained from Saxifraga tangutica first time.