5-HT is an important substance, which plays a crucial role in adjusting mood. The decreasing of composition of 5-HT2AR is the main cause of depression. 5-HT2AR mainly distributes in the cerebral cortex. Many researches have proved that the raised funtion of 5-HT2AR is the main cause of the depressive illness. CUMS is the first model that imitates the human depression, which can copy the core symptoms, namely anhedonia, closely similar to the fundamental pathological physiology change of human beings. That is why the model has become the main one to study 5-HT home and abroad. Many researches have been adopted to observe TCM compound intervention depression in China, and prove that traditional Chinese medicine compound can adjust the function of 5-HT2AR, increase it's content and resist the depression.
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