帕金森病患者不同临床分期焦虑与运动障碍关系研究
Study on relationship between anxiety disorder and motor symptoms in patients with Parkinson's disease in different clinical stages
杨文学 1李敏 1李明伟 1齐小荣 1杨明会1
作者信息
- 1. 中国人民解放军总医院第六医学中心中医医学部,北京 100048
- 折叠
摘要
目的:研究帕金森病(PD)患者不同临床分期焦虑与运动障碍的关系.方法:根据汉密尔顿焦虑量表(HAMA)和Hoehn-Yahr分期量表将PD患者分为早期焦虑组/非焦虑组(A1组/B1组)和中晚期焦虑组/非焦虑组(A2组/B2组).采用统一PD评定量表的第二和第三部分(UPDRS-Ⅱ和UPDRS-Ⅲ)、肌肉张力检测仪、10 m步行实验(10MWT)和"行走-起立"计时测试(TUGT)测评患者运动功能.结果:A1组UPDRS-Ⅱ、UPDRS-Ⅲ、TUTG高于B1组;A1组上肢肌张力、步长低于B1组,差异具有统计学意义(P＜0.05).经相关性分析,早期PD患者焦虑与TUGT、步长、UPDRS-Ⅱ、UPDRS-Ⅲ具有相关性(P＜0.05).结论:焦虑在PD患者中高发,也是加剧PD运动障碍的重要因素,且对PD早期运动功能的影响更为显著.
Abstract
Objective:To study the relationship between anxiety and movement disorders in patients with Parkinson's disease(PD)at different clinical stages.Methods:Patients with PD were divided into early anxiety group/non-anxiety group(group A1/group B1)and middle and late anxiety group/non-anxiety group(group A2/group B2)according to Hamilton anxiety scale(HAMA)and Hoehn-Yahr grading scale.The second and third parts of the unified PD rating scale(UPDRS-Ⅱ and UPDRS-Ⅲ),muscle tonometry,the 10 m walk test(10MWT)and the'walk-stand'timing test(TUGT)were used to measure the patients'motor function.Results:The UPDRS-Ⅱ and UPDRS-Ⅲ scores and TUTG in group A1 were higher than those in group B1;upper limb muscle tone level and stride length were lower in group A1 than in group B1,and the differences were statistically significant(P＜0.05).By correlation analysis,anxiety was correlated with TUGT,step length,UPDRS-Ⅱ,and UPDRS-Ⅲ in patients with early PD(P＜0.05).Conclusion:Anxiety is highly prevalent in patients with PD,it is also an important factor that exacerbates motor impairment in PD and has a more significant effect on motor function in early PD.
关键词
帕金森病/焦虑/肌张力/运动障碍Key words
Parkinson's disease(PD)/Anxiety/Muscle tension/Dyskinesia引用本文复制引用
基金项目
国家自然科学基金重点项目(82130117)
出版年
2024
NETL
NSTL
万方数据