中药口服液体制剂物料流浸膏的性质表征体系构建与应用
Construction and application of characterization system of material liquid extract of oral liquid preparation of traditional Chinese medicine
丁珂 1杨挡 1孙娥 1李超 2朱法根 2邵建国 2熊志伟 3封亮 3贾晓斌3
作者信息
- 1. 南京中医药大学附属中西医结合医院,江苏省中医药研究院,国家中医药管理局中药口服释药系统重点研究室,南京 210028
- 2. 济川药业集团有限公司,江苏省儿科中药与特色制剂重点实验室,泰兴 225400
- 3. 中国药科大学中药学院,南京 211198
- 折叠
摘要
目的:对流浸膏性质进行系统性研究,构建中药流浸膏物料性质表征体系.方法:搜集表征中药提取物流浸膏的相关性质构建物料性质表征体系,将其应用于示范品种蒲地蓝消炎口服液,对三味合提流浸膏和黄芩流浸膏性质进行测定并与制剂性质进行关联分析.结果:构建了包括空间结构、面性质、体性质、气味性质、理化性质和物质构成共6个层面、20项性质、41项性质指标的中药流浸膏物料性质表征体系;发现了与中药口服液体制剂的有效性、稳定性和口感密切相关的性质是溶解性、酸碱性和味道性质.结论:中药流浸膏物料性质表征体系的建立可以指导中药口服液体制剂的剂型改进与技术优化.
Abstract
Objective:To study the properties of liquid extract systematically,and to establish a system for characterizing the properties of Chinese herbal extract.Methods:Collected the related properties of the extract of traditional Chinese medicine(TCM)to construct the characterization system of the extract of TCM,and applied it to the Pudilan Xiaoyan Oral Liquid,the properties of the three medicinal liquid extract and Scutellaria baicalensis liquid extract were determined and correlated with the properties of the preparation.Results:A system for characterizing the properties of Chinese medicinal herb extract was constructed,which consists of 6 levels,20 properties and 41 properties,including spatial structure,surface properties,body properties,odor properties,physical and chemical properties and material composition.It was found that the properties closely related to the effectiveness,stability and taste of oral liquid preparations of TCM were solubility,acidity and taste.Conclusion:The establishment of the characterization system can guide the improvement of dosage form and technology optimization of oral liquid preparation of TCM.
关键词
中药口服液体制剂/流浸膏/物料性质表征体系/蒲地蓝消炎口服液/溶解性/酸碱性/味道Key words
Oral liquid preparation of traditional Chinese medicine/Liquid extract/Material property characterization system/Pudilan Xiaoyan Oral Liquid/Solubility/Acid and alkali/Taste引用本文复制引用
基金项目
国家重点研发计划(2018YFC1706902)
江苏省儿科中药与特色制剂重点实验室开放课题(BM2019011)
江苏省科技成果转化专项资金(BA2020077)
江苏省医学创新团队项目(CXTDB2017003)
国家中医药管理局2022年中央财政转移支付地方项目(2022GJJZDYJS-01)
江苏省研究生实践创新计划项目(SJCX21-0716)
出版年
2024
国家科技期刊平台
NSTL
万方数据