Historical evolution and modern research progress of processing Strychni Semen
Strychni Semen is a commonly used traditional Chinese medicine in clinic.Its processing has a long history and various forms.In ancient times,there were various processing methods,such as net processing,cutting processing,stir-frying processing,oil processing,licorice processing,ephedra processing,children's stool processing,oil removal processing,yellow wine processing,tofu processing and so on.With the historical evolution,some characteristic processing methods gradually disappeared.Nowadays,the main processing methods are net processing,oil processing and sand scalding.Local processing norms record a lot of Strychnic Semen processing methods.There is a phenomenon of'multiple methods in one place and various methods in various places',and there is a lack of unified quality standards,resulting in uneven quality of Strychnic Semen decoction pieces.In recent years,patients taking Strychni Semen and its preparations in clinic often have different degrees of toxic and side effects.The main alkaloids contained in Strychni Semen are both active ingredients and toxic ingredients.Different processing methods have different degrees of reduction in the medicinal properties and toxic and side effects of Strychni Semen.The authors summarized the historical evolution of the processing of Strychnic Semen and the research status of attenuation,and analyzed the problems existing in the current research progress of Strychnic Semen processing,aiming to lay a foundation for the subsequent research on the processing mechanism,pharmacodynamics and toxic material basis of Strychnic Semen.