Study on development of a rat bladder meridian massage and pressing instrument and its effect on an anxiety rat model
Objective:An intelligent simulation technique parameter instrument was developed to explore the anxiolytic action mechanism of the instrument on anxious rats.Methods:Using YLS-34A Rat Bladder Meridian Massage and Pressing Instrument(referred to as YLS-34A Massage and Pressing Instrument)to simulate the rats.Thirty SD rats were randomly divided into a control group,a model group,and a bladder massage group(Massage of bladder meridian,BMM group).After intervention,compared the behavior of sugar water preference test,tail suspension test and forced swimming test;detect the related protein pathway of hippocampal inflammasome.Results:YLS-34A Massage and Pressing Instrument can effectively fix rats,automatically and accurately map back acupoints and improve anxiety-like behavior;significantly reduce the anxiety rats'anxiety-like behaviors such as sugar water preference,hanging tail motionless time,forced swimming time,etc.;significantly reduce the protein expression of NLRP3/NF-κB signaling pathway in hippocampus of anxiety rats(P＜0.05).Conclusion:YLS-34A Massage and Pressing Instrument can provide a reliable tool for the improvement of anxiety-like behavior.It is related to the inhibition of hippocampal NLRP3/NF-κB signaling.
Anxiety disorderBladder meridian massageAnimal modelPressing manipulative instrumentInflammasome
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