Study on the correlation between the distribution of traditional Chinese medicine syndrome elements and intestinal flora in different atrophic areas of chronic atrophic gastritis
Objective:To explore the correlation between the distribution of traditional Chinese medicine(TCM)syndrome elements and intestinal flora in different atrophy degrees of chronic atrophic gastritis(CAG).Methods:A total of 120 CAG patients were classified by Kimura-Takemoto classification under microscope,and syndrome differentiation method was used to analyze the distribution difference of syndrome elements in different atrophic degrees of CAG.In addition,16S rRNA sequencing method was used to detect intestinal flora,find the difference of flora,and analyze the evolution characteristics and biological basis of CAG.Results:The distribution of syndrome elements:The common disease-position syndrome elements from high to low of CAG are:stomach,liver,spleen,and mind.Common disease location syndrome elements,the syndrome elements are:qi stagnation,heat,yin deficiency,dampness,phlegm,qi deficiency,food accumulation,yang deficiency,yang hyperactivity,blood deficiency and blood stasis.When CAG atrophy ranges from C-1 to C-3,The proportion of disease location syndrome and mind gradually increased.The proportion of solid syndrome element was decreasing and that of deficiency syndrome element was increasing.The pathogenesis of the disease was changed from real to virtual and mixed with virtual and real.The difference of intestinal flora distribution in different atrophic degrees of CAG:a total of 4 biomarkers were obtained by LEfse analyse.In terms of species composition,at the genus level,Prevotella was more abundant in group C-3 than in group C-1(P＜0.05).The abundance of Bifidobacterium in C-3 group was significantly lower than that in C-1 group(P＜0.05).Conclusion:The diversity of intestinal flora and the abundance of specific flora were different in patients with different atrophy degrees of CAG,dysregulation of intestinal flora is closely related to the occurrence and development of CAG.
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