"肺虚络瘀"病机观与"机械应力异常"在特发性肺纤维化发病过程中的相关性
Correlation between'lung deficiency and collateral blood stasis'and'abnormal mechanical stress'in the pathogenesis of idiopathic pulmonary fibrosis
邹吉宇 1庞立健 2吕晓东 1臧凝子 3王天娇2
作者信息
- 1. 辽宁中医药大学,沈阳 110847
- 2. 辽宁中医药大学附属医院,沈阳 110032
- 3. 辽宁中医药大学,沈阳 110847;辽宁中医药大学附属医院,沈阳 110032
- 折叠
摘要
以"肺虚络瘀"中医病机观为理论指导,结合现代医学临床研究,对特发性肺纤维化(IPF)病理过程中出现的异常机械应力及"IPF外周-中心向心性进展"进行分析,认为机械应力异常(机械拉伸、机械内稳态失衡、持续升高的机械应力)为IPF重要病理改变,并且"机械应力异常"与"肺虚络瘀"具有相同的病机演变格局,深入探究"机械应力异常"与IPF"肺虚络瘀"中医病机观的相关性,全面诠释"肺虚络瘀"的科学内涵,进一步从力学角度解释调控机械应力有望成为IPF新的治疗方向.
Abstract
Guided by the traditional Chinese medicine(TCM)pathogenesis of'lung deficiency and collateral blood stasis',combined with modem clinical research,abnormal mechanical stress and'peripheral-central region centripetal progress of idiopathic pulmonary fibrosis(IPF)'in the pathological process of IPF were analyzed.It was considered that abnormal mechanical stress(mechanical tension,imbalance of mechanical homeostasis and continuously increasing mechanical stress)was an important pathological change of IPF.Abnormal mechanical stress and'lung deficiency and collateral blood stasis'have the same pathogenesis evolution pattern.Deeply explore the correlation between abnormal mechanical stress and TCM pathogenesis theory of IPF'lung deficiency and collateral blood stasis',comprehensively interpret the scientific connotation of'lung deficiency and collateral blood stasis',and further explain and regulate mechanical stress from the perspective of mechanics,which is expected to become a new treatment direction of IPF.
关键词
肺虚络瘀/特发性肺纤维化/机械应力/相关性Key words
Lung deficiency and collateral blood stasis/Idiopathic pulmonary fibrosis(IPF)/Mechanical stress/Correlation引用本文复制引用
基金项目
国家自然科学基金面上项目(82274440)
国家自然科学基金青年科学基金项目(82004294)
辽宁省"兴辽英才计划"高水平创新创业团队项目(XLYC1808011)
出版年
2024
NETL
NSTL
万方数据