首页|黄瓜籽防治骨质疏松症的古今应用及现代研究进展

黄瓜籽防治骨质疏松症的古今应用及现代研究进展

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黄瓜籽为葫芦科黄瓜属植物Cucumis sativus Linn.的干燥成熟种子,在民间常用于接骨壮骨,效果显著,收载于《辽宁常用中草药手册》和《中华本草》中,具有续筋接骨、祛风消痰的功效.近几年来,一些学者研究发现黄瓜籽通过促进去势骨质疏松模型大鼠骨折愈合及骨骼重塑,减缓去势后骨质流失速度等机制达到防治骨质疏松的目的.另外,黄瓜籽中还含有多种潜在的抗骨质疏松作用成分,如植物甾醇、油酸、黄酮类成分及微量元素等,可通过多种作用机制发挥抗骨质疏松作用.此外,黄瓜籽还具有抗氧化、抗血栓、保护牙齿、调节肠道菌群及调节糖脂代谢等作用,由于菌群失调、糖脂代谢紊乱、氧化应激等都与骨质疏松密切相关,可进一步开展研究及开发利用.
Application and research progress of cucumber seed in prevention and treatment of osteoporosis in ancient and modern times
Cucumber seeds are the dry and mature seeds of Cucumis sativus Linn.,a plant of the Cucurbitaceae family,commonly used in folk practice for bone bonding and strengthening.Cucumber seeds have the effects of strengthening tendons and bones,dispelling pathogenic wind,and eliminating phlegm.They are recorded in the Liaoning Common Chinese Herbal Medicine Handbook and Chinese Materia Medica.In recent years,some scholars have found that cucumber seeds can prevent and treat osteoporosis by promoting fracture healing and bone remodeling in ovariectomized osteoporosis model rats,thus slowing down the rate of bone loss after ovariectomy.Additionally,cucumber seeds contain various potential anti-osteoporosis ingredients,such as phytosterols,oleic acid,flavonoids,and trace elements,etc..These compounds can exert anti-osteoporosis effects through various mechanisms of action.Furthermore,cucumber seeds also possess antioxidant,antithrombotic,tooth protection,and gut microbiota regulation properties,as well as the ability to regulate glucose and lipid metabolism.Since dysbiosis of the microbiota,disorders of glucose and lipid metabolism,and oxidative stress are closely related to osteoporosis,further research and development can be carried out to utilize cucumber seeds.

Cucumber seedOsteoporosis(OP)Application in ancient and modern timesResearch progressComponentPharmacologic action

宁梦真、孙银玲、丁纯洁、郑宏宇、赵娢、陈丽艳

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黑龙江省中医科学院,哈尔滨 150036

黄瓜籽 骨质疏松症 古今应用 研究进展 成分 药理作用

国家自然科学基金联合基金项目现代农业产业技术体系建设专项黑龙江省财政专项哈尔滨市应用技术研究与开发资金

U20A20400CARS-21CZKYF2021A0022017RAQXJ236

2024

中华中医药杂志
中华中医药学会

中华中医药杂志

CSTPCD北大核心
影响因子：1.135
ISSN：1673-1727
年,卷(期)：2024.39(2)
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