黄瓜籽防治骨质疏松症的古今应用及现代研究进展
Application and research progress of cucumber seed in prevention and treatment of osteoporosis in ancient and modern times
宁梦真 1孙银玲 1丁纯洁 1郑宏宇 1赵娢 1陈丽艳1
作者信息
- 1. 黑龙江省中医科学院,哈尔滨 150036
- 折叠
摘要
黄瓜籽为葫芦科黄瓜属植物Cucumis sativus Linn.的干燥成熟种子,在民间常用于接骨壮骨,效果显著,收载于《辽宁常用中草药手册》和《中华本草》中,具有续筋接骨、祛风消痰的功效.近几年来,一些学者研究发现黄瓜籽通过促进去势骨质疏松模型大鼠骨折愈合及骨骼重塑,减缓去势后骨质流失速度等机制达到防治骨质疏松的目的.另外,黄瓜籽中还含有多种潜在的抗骨质疏松作用成分,如植物甾醇、油酸、黄酮类成分及微量元素等,可通过多种作用机制发挥抗骨质疏松作用.此外,黄瓜籽还具有抗氧化、抗血栓、保护牙齿、调节肠道菌群及调节糖脂代谢等作用,由于菌群失调、糖脂代谢紊乱、氧化应激等都与骨质疏松密切相关,可进一步开展研究及开发利用.
Abstract
Cucumber seeds are the dry and mature seeds of Cucumis sativus Linn.,a plant of the Cucurbitaceae family,commonly used in folk practice for bone bonding and strengthening.Cucumber seeds have the effects of strengthening tendons and bones,dispelling pathogenic wind,and eliminating phlegm.They are recorded in the Liaoning Common Chinese Herbal Medicine Handbook and Chinese Materia Medica.In recent years,some scholars have found that cucumber seeds can prevent and treat osteoporosis by promoting fracture healing and bone remodeling in ovariectomized osteoporosis model rats,thus slowing down the rate of bone loss after ovariectomy.Additionally,cucumber seeds contain various potential anti-osteoporosis ingredients,such as phytosterols,oleic acid,flavonoids,and trace elements,etc..These compounds can exert anti-osteoporosis effects through various mechanisms of action.Furthermore,cucumber seeds also possess antioxidant,antithrombotic,tooth protection,and gut microbiota regulation properties,as well as the ability to regulate glucose and lipid metabolism.Since dysbiosis of the microbiota,disorders of glucose and lipid metabolism,and oxidative stress are closely related to osteoporosis,further research and development can be carried out to utilize cucumber seeds.
关键词
黄瓜籽/骨质疏松症/古今应用/研究进展/成分/药理作用Key words
Cucumber seed/Osteoporosis(OP)/Application in ancient and modern times/Research progress/Component/Pharmacologic action引用本文复制引用
基金项目
国家自然科学基金联合基金项目(U20A20400)
现代农业产业技术体系建设专项(CARS-21)
黑龙江省财政专项(CZKYF2021A002)
哈尔滨市应用技术研究与开发资金(2017RAQXJ236)
出版年
2024
NETL
NSTL
万方数据