摘要
目的:探讨糖尿病患者血糖波动与中医证候之间的关联性.方法:运用动态血糖监测系统评估住院糖尿病患者的血糖波动特点,并进行中医证候分类及积分,运用多元线性回归相关分析血糖波动参数与证候积分之间的关联.结果:研究纳入72例糖尿病患者,线性回归结果显示中医阴虚证积分(P=0.023)、阳虚证积分(P=0.032)、血瘀证积分(P=0.003)分别与平均血糖波动幅度(MAGE)呈显著线性正相关,回归系数B分别为0.141、0.109、0.134;阳虚证积分(P=0.018)、血瘀证积分(P=0.000)分别与24 h血糖标准差呈显著线性正相关,回归系数B分别为0.052、0.071;阳虚证积分(P=0.045)、血瘀证积分(P=0.011)与日间血糖平均绝对差呈显著线性正相关,回归系数B分别为0.059、0.069.散点图显示MAGE与中医证候总积分、阴虚证、阳虚证、血瘀证积分大致呈线性正相关趋势,其中MAGE与血瘀证的散点图中各点的离散程度最低、最集中.结论:糖尿病患者的血糖波动与中医证候相关,血糖波动可能与阴虚、阳虚、血瘀证有关,其中与血瘀证的关联性最密切.
Abstract
Objective:To explore the association between glucose variability and traditional Chinese medicine(TCM)syndrome in patients with diabetes mellitus(DM).Methods:Glucose variability was evaluated by continuous glucose monitoring system,meanwhile TCM syndrome classification and cumulative scores were conducted in hospitalized patients with DM,and then multivariate linear regression was used to analyze the correlation between glucose variability parameters and TCM syndrome score.Results:The current study preformed 72 DM patients.Linear regression results showed that the score of yin deficiency syndrome(P=0.023),yang deficiency syndrome(P=0.032)and blood stasis syndrome(P=0.003)were significantly and positively correlated with the mean amplitude of glycemic excursion(MAGE),respectively,and the regression coefficients B were 0.141,0.109 and 0.134,respectively.The scores of yang deficiency syndrome(P=0.018)and blood stasis syndrome(P=0.000)were positively correlated with the standard deviation of 24 h blood glucose,respectively,and the regression coefficients B were 0.052 and 0.071,respectively.The scores of yang deficiency syndrome(P=0.045)and blood stasis syndrome(P=0.011)were significantly positively correlated with the mean absolute difference in the mean of daily differences,and the regression coefficients B were 0.059 and 0.069,respectively.The scatter diagram showed that MAGE presented a linear positive correlation trend with the score of TCM syndromes including the total score of TCM syndrome,yin deficiency syndrome,yang deficiency syndrome and blood stasis syndrome roughly,among which the diagram of MAGE and the score of blood stasis syndrome showed the most concentrated scattered degree of the points.Conclusion:Glucose variability may be correlated to the TCM syndromes in DM patients.The glucose variability may be related to the yin deficiency,yang deficiency and blood stasis syndrome,among which blood stasis syndrome may be the most closely relative.
基金项目
国家自然科学基金青年科学基金项目(82104827)
北京协和医院中央高水平医院临床科研专项(2022-PUMCH-A-265)
国家科技期刊平台
NSTL
万方数据