Effects of FLG and K17 protein expression and skin barrier function by comprehensive Chinese medicine treatment program on skin lesion tissues of psoriasis patients with spleen-deficiency and dampness-rich type
Objective:To investigate the effects of comprehensive Chinese medicine treatment program on filaggrin(FLG)and keratin 17(K17)protein expression and skin barrier function in skin lesion tissues of psoriasis patients with spleen-deficiency and dampness-rich type.Methods:A control group based on oral Methotrexate Tablets,Topical Carbotriol Cream and NB-UVB phototherapy was established and a treatment group based on oral Jianpi Jiedu Decoction,topical Chinese medicine bath,Pulian Cream and cupping therapy was established,and both groups were treated for 4 weeks.The expression of FLG and K17 protein and skin barrier function of target skin lesion tissue[trans epidermal water loss(TWEL),stratum corneum hydration]and psoriasis area and severity index(PASI)score were compared.It mainly analyzed the clinical manifestation of the comprehensive scheme and the specific effect on the skin barrier.Results:After treatment,the PASI values of the two groups decreased comprehensively than before treatment(P＜0.01),FLG protein was almost always expressed in the stratum corneum in the lesion tissue,uniformly distributed and strongly expressed than before treatment(P＜0.01),and K17 protein was extremely weakly expressed or even not expressed.After treatment,the water content of stratum corneum in two groups increased comprehensively than before treatment(P＜0.01),and the TEWL fell down(P＜0.01).The clinical efficacy of treatment group was better than control group(P＜0.05).Conclusion:The comprehensive Chinese medicine treatment program for psoriasis with spleen-deficiency and dampness-rich type can reduce the symptoms of skin lesions,affect the expression of FLG and K17 proteins in skin lesion tissues,improve the skin barrier function,and enhance the clinical treatment effect.
PsoriasisComprehensive Chinese medicine treatment programSkin barrierFilaggrin(FLG)Keratin 17(K17)Spleen-deficiency and dampness-richClinical efficacy
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