Influence of retinal microenvironment hypoxia on retinal ganglion cells apoptosis of glaucoma based on theory of'harmful hyperactivity and responding inhibition'
Glaucoma is the first irreversible blinding eye disease in the world.The apoptosis of retinal ganglion cells(RGCs)is the key to resulting in visual field defect,and hypoxia of retinal microenvironment is considered as the early and prominent event of apoptosis of glaucoma RGCs.The theory of'harmful hyperactivity and responding inhibition'is an important principle for traditional Chinese medicine to understand the physiological system and pathological imbalance and guide the regulation of drugs,revealing the internal regulation mechanism of objects control and self stabilization.Corresponding to the nature,the body also needs to rely on the laws of regulation to maintain a steady state of visceral harmony.The whole process of the occurrence and development of apoptosis in glaucoma RGCs runs through the process of'insufficient control,excessive damage'.The deficiency of spleen qi and lack of control caused the failure to maintain the dynamic equilibrium of the retinal redox system,resulting in the disharmony of viscera's qi and blood,phlegm turbidness and blood stasis endogenous,hyperactivity becoming harmful,and the middle eye veins were being obstructed.It is manifested as accumulation of oxygen free radicals in cells,aggravating retinal hypoxia and RGCs apoptosis.In combination with the characteristics of glaucoma with qi deficiency as the foundation and turbidity and stasis as the target,we should take'inheriting and controlling it,restraining its hyperactivity'as the treatment principle and select prescription to trengthen water for regulating fire,promote yang for strengthening spleen,and promote the circulation of collaterals.As a result,the regulating function of visceral function can be effectively restored to remove evil,and then tissue hypoxia be improved,the apoptosis of RGCs be inhibited,and visual function be enhanced.
Harmful hyperactivity and responding inhibitionGlaucomaHypoxiaRetinal ganglion cells(RGCs)PathogenesisTreatment principles
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