针刺抗炎的神经免疫调节机制探析
Exploration of the neuro-immune regulation mechanism of acupuncture anti-inflammation
樊泽至 1窦报敏 1李艳伟 1付疆疆 1刘琪 1李柠岑 1徐枝芳 2郭义1
作者信息
- 1. 天津中医药大学实验针灸学研究中心,天津 301617
- 2. 天津中医药大学实验针灸学研究中心,天津 301617;天津中医药大学针灸推拿学院,天津 301617
- 折叠
摘要
慢性炎性疾病和多种慢性疾病都伴随炎症反应,长期无序、失控的炎症反应会持续地损伤细胞和组织,导致器官组织功能失调或丧失.针刺可以缓解多个系统的慢性炎症,主要体现在调节巨噬细胞、T细胞、NK细胞等免疫细胞的信号通路、极化和功能.针刺可激活穴区的躯体传入通路,将信息传递到脊髓、脑干和下丘脑等神经元.高级中枢整合针刺信息后,通过胆碱能、迷走-肾上腺髓质多巴胺和交感神经通路,及下丘脑-垂体-肾上腺轴等,释放神经递质、激素等作用于免疫细胞发挥抗炎作用.因此,阐明针刺抗炎作用规律及机制可为针刺治疗优势病种的临床应用提供科学依据,更好地实现针刺精准治疗的临床转化.
Abstract
Chronic inflammatory diseases and multiple chronic disorders are accompanied by an inflammatory response,while a long-term disorganized and uncontrolled inflammatory response continues to damage cells and tissues,resulting in dysfunction or loss of organs and tissues.Acupuncture has been found to alleviate chronic inflammation in multiple systems,primarily through its modulatory effects on immune cell signaling pathways,polarization and function in macrophages,T cells and NK cells.Acupuncture activates somatic afferent pathways within acupoints that convey information to spinal cord,brainstem and hypothalamus neurons.After integrating acupuncture-induced information in the high-level central centers,they release neurotransmitters and hormones that act on immune cells to exert anti-inflammatory effects through efferent nervous systems including the cholinergic anti-inflammatory pathway,vagal-adrenal medullary dopamine pathway,sympathetic pathway and hypothalamus-pituitary-adrenal axis.Therefore,the elucidation of acupuncture effect regulation and mechanism may provide a scientific basis for acupuncture indication treatment,and better realize the clinical translation of acupuncture precision treatment.
关键词
针刺/抗炎/神经免疫Key words
Acupuncture/Anti-inflammation/Neuro-immune引用本文复制引用
基金项目
国家自然科学基金重点项目(82030125)
出版年
2024
NETL
NSTL
万方数据