Exploration of the neuro-immune regulation mechanism of acupuncture anti-inflammation
Chronic inflammatory diseases and multiple chronic disorders are accompanied by an inflammatory response,while a long-term disorganized and uncontrolled inflammatory response continues to damage cells and tissues,resulting in dysfunction or loss of organs and tissues.Acupuncture has been found to alleviate chronic inflammation in multiple systems,primarily through its modulatory effects on immune cell signaling pathways,polarization and function in macrophages,T cells and NK cells.Acupuncture activates somatic afferent pathways within acupoints that convey information to spinal cord,brainstem and hypothalamus neurons.After integrating acupuncture-induced information in the high-level central centers,they release neurotransmitters and hormones that act on immune cells to exert anti-inflammatory effects through efferent nervous systems including the cholinergic anti-inflammatory pathway,vagal-adrenal medullary dopamine pathway,sympathetic pathway and hypothalamus-pituitary-adrenal axis.Therefore,the elucidation of acupuncture effect regulation and mechanism may provide a scientific basis for acupuncture indication treatment,and better realize the clinical translation of acupuncture precision treatment.
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