Effects of'soothing the liver and regulating the mind'adjunct points acupuncturing on sleep cycle in rats with post-traumatic stress disorder sleep disorder
Objective:To observe the effects of'soothing the liver and regulating the mind'adjunct points acupuncturing on 12-hour daytime abnormal sleep cycle in post-traumatic stress disorder(PTSD)model rats.Methods:Sixty rats were randomly divided into operation group,model group,grasping group,medicine group and acupuncture group,12 rats in each group.Except the eperation group,the PTSD sleep disorder rat model was established by compound stress method after the electrode and socket were implanted.After modeling,the medicine group,acupuncture group,and grasping group were respective with paroxetine hydrochloride,'soothing the liver and regulating the mind'acupuncture intervention,and grasping fixation.The daytime 12 h sleep electroencephalogram(EEG)was recorded to obtain sleep latency,wakeing-sleep cycle and sleep phase.Results:Compared with the operation group,the sleep latency and wake period of the model group were prolonged(P＜0.01),every sleep period and 8:00-9:00 and 15:00-18:00 sleep were shortened(P＜0.01,P＜0.05).Compared with grasping group,sleep latency and wake period of rats in medicine group and acupuncture group were shortened(P＜0.01),every sleep period and sleep from 8:00 to 10:00 and 14:00 to 16:00 of rats in medicine group were prolonged(P＜0.01,P＜0.05).In the acupuncture group,every sleep period and the sleep of the rats from 8:00-9:00,12:00-13:00,15:00-18:00 were prolonged(P＜0.01,P＜0.05).Compared with the medicine group,the sleep of rats in the acupuncture group was shorter from 9:00-10:00 and longer from 16:00-17:00(P＜0.05).Conclusion:'Soothing the liver and regulating the mind'adjunct points acupuncture and Paroxetine Hydrochloride can regulate abnormal EEG and improve sleep in PTSD sleep disorder model rats.However,compared with drug intervention,acupuncture is more targeted,dose not cause drowsiness,and its effect is more stable.
AcupunctureSoothing the liver and regulating the mindPost-traumatic stress disorderSleep disordersAnimal modelSleep cycleElectroencephalogram
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