类风湿关节炎伴甲状腺功能异常临床分析
Clinical analysis of rheumatoid arthritis with thyroid dysfunction
杨显娜 1殷建美 2王志敏 2晏蔚田 2王兴强 3刘维超 3凌丽 2唐海倩 2孟凡雨 2张昊喆 2彭江云3
作者信息
- 1. 云南中医药大学第一临床医学院,昆明 650011;保山中医药高等专科学校,保山 678000
- 2. 云南中医药大学第一临床医学院,昆明 650011
- 3. 云南中医药大学第一附属医院,昆明 650021
- 折叠
摘要
目的:探究类风湿关节炎伴发甲状腺功能异常的情况和临床意义.方法:采用回顾性研究的方法,纳入871例RA患者为病例组,1 742名健康体检者为对照组.回顾性分析免疫学指标、甲状腺功能及常规的实验室检查项目,评估RA患者的甲状腺功能状况,并对类风湿关节炎患者中甲状腺功能异常和正常的自身抗体、常规实验室检查项目进行组间比较及相关性分析.结果:RA组甲状腺功能异常216例(24.80％),对照组甲状腺功能异常204例(11.71％),两组差异有统计学意义(P＜0.05).其中,甲状腺功能亢进11例,亚临床型甲状腺功能亢进1例,甲状腺功能减退132例,亚临床型甲状腺功能减退64例,低T3/T4综合征8例.RA组TSH、TPOAb较对照组升高(P＜0.01,P＜0.05),TT3、FT3较对照组降低(P＜0.01,P＜0.05);甲状腺功能异常和正常RA患者ANA抗体阳性率差异有统计学意义(P＜0.05).结论:RA患者易伴发甲状腺功能异常,以甲状腺功能低下最为常见,有必要定期进行甲状腺筛查.
Abstract
Objevtive:To explore the situation and clinical significance of rheumatoid arthritis with thyroid dysfunction.Methods:A retrospective study was carried out,including 871 RA patients as the case group and 1 742 healthy persons as the control group.The immunologic indexes,thyroid function and routine laboratory examination items were retrospectively analyzed to evaluate the thyroid function of RA patients,and the abnormal and normal thyroid autoantibodies and routine laboratory tests of RA patients were compared between groups and the correlation analysis was performed.Results:There were 216(24.80％)abnormal thyroid function in RA group and 204(11.71％)abnormal thyroid function in control group.The difference between the two groups was statistically significant(P＜0.05).Among them,there were 11 cases of hyperthyroidism,1 case of subclinical hyperthyroidism,132 cases of hypothyroidism,64 cases of subclinical hypothyroidism,and 8 cases of low T3/T4 syndrome.TSH and TPOAb in RA group were higher than those in control group(P＜0.01,P＜0.05),while TT3 and FT3 were lower than those in control group(P＜0.01,P＜0.05).There was a significant difference in the positive rate of ANA antibody between patients with abnormal thyroid function and normal RA(P＜0.05).Conclusion:Patients with RA are prone to have abnormal thyroid function,and hypothyroidism is the most common.It is necessary to carry out thyroid screening regularly.
关键词
关节炎/类风湿/甲状腺功能/回顾性研究Key words
Arthritis/Rheumatoid/Thyroid function/Retrospective study引用本文复制引用
基金项目
国家中医药局国家中医(类风湿关节炎)临床研究基地建设项目(中国中医药科技函[2018]131号)
国家自然科学基金(82160901)
国家自然科学基金(81960863)
云南省中医(风湿病)临床医学研究中心项目(202102AA310006)
云南省中医药学科后备人才培养项目(云卫中医发展发[2021]1号)
云南省科技厅云南中医学院应用基础研究联合专项(202101AZ070001-201)
出版年
2024
NETL
NSTL
万方数据