Study on the efficacy and mechanism of acupotomy in the treatment of acute phase of vestibular syndrome
Objective:To verify the effectiveness of acupotomy in the treatment of acute phase of vestibular syndrome,and to explore the molecular biological mechanisms of its efficacy.Methods:Sixty patients with acute phase of vestibular syndrome were randomly divided into test group and control group.Patients in the test group were given acupotomy,and patients in the control group were given Betahistine orally.The researchers observed the following indicators before treatment and 30 min,3.5 h,6 h,24 h and 72 h after treatment,namely VSI,DHI,UCLA-DQ,and timing balance test.Twenty patients randomly selected from the test group were taken as the mechanism group,and twenty volunteers recruited from healthy people were taken as the health group.The healthy group did not receive any treatment.Venous blood was drawn from patients in the mechanism group before acupotomy and within 30 minutes after the treatment,and venous blood was drawn from patients in the healthy group after a quiet rest to detect neurotransmitters(DA,NE,HIS,5-HT,GLU).Results:The DHI,VSI,UCLA-DQ scores in the test group decreased at each observation time after treatment(P＜0.05).Within 24 h after intervention the effective rate of the test group was higher than that of the control group during the same period(P＜0.05).The results of neurotransmitters showed that before intervention,GLU,DA,NE,5-HT and HIS in the mechanism group were lower than that in healthy group(P＜0.01).Conclusion:Acupotomy can rapidly relieve vestibular symptoms and restore balance function in patients with acute phase of vestibular syndrome.
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