首页|补肾法调节自噬治疗自然流产的研究思路

补肾法调节自噬治疗自然流产的研究思路

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自然流产是常见的早期妊娠障碍之一,且具有复发倾向,而现代医学治疗流产的方案与手段仍有争论.《黄帝内经》提出了"肾主生殖"理论,成为了中医药安胎的指导思想.目前补肾法安胎疗效已获得中西医认可,但补肾法的安胎机制复杂,其科学内涵尚未完全阐明.自噬是真核细胞内进化高度保守的代谢调控机制,在不同疾病或同一种疾病的不同病理阶段所发挥的作用不一样.目前,自噬在自然流产中扮演的角色尚未明确.文章通过分析自噬与补肾法治疗自然流产的潜在关系,从而拓展补肾安胎作用机制的研究思路,希冀为"肾主生殖"科学内涵提供更多的客观证据.
Research ideas on regulating autophagy with kidney-tonifying method to treat spontaneous abortion
Spontaneous abortion(SA),a common disorder in early pregnancy,has a tendency to recur.However,there is still debate about the schemes and methods of modern medical treatment for SA.The theory of kidney governs reproduction proposed in the Huangdi Neijing has become the guiding principle of traditional Chinese medicine for miscarriage.Currently,the tocolysis effect of kidney-tonifying method has been recognized by both traditional Chinese and Western medicine.However,the mechanism of the kidney-tonifying method in maintaining pregnancy is complex,and its scientific connotation has not been fully explained.Autophagy is a highly conserved metabolic regulation mechanism in eukaryotic cells that plays different roles in various diseases or at different pathological stages of the same disease.Currently,the role of autophagy in SA is not clear.This article explores the potential relationship between autophagy and the treatment of SA using kidney-tonifying method,thereby expanding the research ideas on the mechanism of kidney-tonifying in maintaining pregnancy,with the hope of providing more objective evidence for the scientific meaning of'kidney governs reproduction'.

AutophagySpontaneous abortion(SA)Tonifying the kidney methodJianwei Shoutai PillsKidney governs reproduction

巫海旺、钟艳兰、罗颂平、郜洁

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广州中医药大学第一附属医院,广州 510405

广东省中医临床研究院,广州 510405

广州中医药大学第一临床医学院,广州 510405

自噬 自然流产 补肾法 减味寿胎丸 肾主生殖

国家自然科学基金广东省基础与应用基础研究基金广州市基础研究计划市校(院)联合资助市重点实验室建设项目广东省重点领域研发计划广州中医药大学第一附属医院中青年骨干人才培育项目(2023)

822051582021A15151110662022010203832020B1111100003中医一院[2023]186号

2024

中华中医药杂志
中华中医药学会

中华中医药杂志

CSTPCD北大核心
影响因子：1.135
ISSN：1673-1727
年,卷(期)：2024.39(4)
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