从抑制异常血管新生探讨中医药治疗糖尿病肾病的补虚通络法
Discussion on tonifying deficiency and tongluo method of traditional Chinese medicine in treating diabetic nephropathy from inhibiting abnormal angiogenesis
林敏 1郭玉琴 1范丽妃 1郭静 1鲁玉辉1
作者信息
- 1. 福建中医药大学中医学院,福州 350122
- 折叠
摘要
异常血管新生是糖尿病肾病(DN)发生发展的重要因素,中医认为DN异常血管新生以正气亏虚为本,痰瘀浊毒为标.文章结合DN发病特点,从络病理论人手探讨中医补虚通络法对DN异常血管新生的认识,梳理常见相关分子靶点并总结近年来重要中药单体、单味药、复方(药对)调控DN异常血管新生的研究现状,证实了不少中药可通过不同途径、靶点抑制DN异常血管新生,为进一步深入研究中医药抑制DN异常血管新生提供参考.
Abstract
Abnormal angiogenesis is an important factor in the occurrence and development of diabetic nephropathy(DN).Traditional Chinese medicine believes that the pathogenesis of DN abnormal angiogenesis is based on the deficiency of vital energy and marked by phlegm,blood stasis,turbid toxin.Based on the pathogenesis characteristics of DN,this paper discusses the understanding of abnormal angiogenesis of DN from perspective of tonifying deficiency and tongluo method in traditional Chinese medicine collateral disease theory,combs common related molecular targets,and summarizes the research status of important monomer-single herb-compound(herb pair)regulation of DN abnormal angiogenesis in recent years,which confirms that many Chinese medicine can inhibit DN angiogenesis through different ways and targets,providing a reference for further in-depth research on Chinese medicine's inhibition of abnormal angiogenesis of DN.
关键词
糖尿病肾病/血管新生/络病理论/补虚通络/中医药疗法Key words
Diabetic nephropathy(DN)/Angiogenesis/Collateral disease theory/Tonifying deficiency and tongluo method/Traditional Chinese medicine therapy引用本文复制引用
基金项目
国家自然科学基金(82104713)
福建省自然科学基金(2023J01335)
福建中医药大学高层次人才科研启动基金(X2020007-人才)
出版年
2024
NETL
NSTL
万方数据