首页|基于因子分析和聚类分析探讨慢性阻塞性肺疾病稳定期的临床特征

基于因子分析和聚类分析探讨慢性阻塞性肺疾病稳定期的临床特征

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目的:分析慢性阻塞性肺疾病(COPD)稳定期患者的临床症状、体征分布情况,深化对本病脏腑功能特征的认识.方法:采用观察性研究方法,通过构成比分析、因子分析和聚类分析等多种方法分析COPD稳定期患者的主要症状、兼症及舌脉等情况,阐释其临床特征和脏腑功能特征.结果:共纳入231例COPD稳定期患者,构成比分析显示,主症出现频次由多到少依次为咳嗽、喘息、气短和胸闷;兼症频次较多的前10位依次为起夜频数、畏寒肢冷、口干、入睡困难、眠浅易醒、自汗、耳鸣、乏力、食欲减退、腹胀;舌象以暗红舌、薄白苔为主,脉象以细脉、沉细脉、弦细脉为主.因子分析显示,症状变量旋转后得到14个公因子.R型层次聚类将COPD稳定期临床症状、体征分为三大类,较为客观地反映出COPD稳定期的临床特征.结论:临床COPD稳定期患者表现为虚实并存、寒热错杂征象,呈现出肺脾核心两本多脏虚的脏腑功能特征.
Clinical characteristics of stable chronic obstructive pulmonary disease based on factor analysis and cluster analysis
Objective:To analyze the distribution of clinical symptoms and signs in patients with stable chronic obstructive pulmonary disease(COPD)and deepen the understanding of the functional characteristics of zang-fu organs.Methods:The observational research method was used to uniformly input the basic data,main symptoms,concurrent symptoms,tongue and pulse,etc.of the included patients with stable COPD.The distribution of symptoms and signs in stable COPD was mined through component ratio analysis,factor analysis and cluster analysis to explain the functional characteristics of zang-fu organs.Results:A total of 231 patients with stable COPD were included.The component ratio analysis showed that main symptoms of the included patients were cough,wheezing,shortness of breath,and chest tightness in descending order.The other symptoms in top 10 were night frequency,chills and cold limbs,dry mouth,difficulty falling asleep,light sleep and easy awakening,spontaneous perspiration,tinnitus,fatigue,loss of appetite,abdominal distension.The tongue color was mainly dark red and the tongue coating is mainly thin white coating.The pulse condition was mainly thin veins.Factor analysis obtained 14 common factors through factor rotation of symptom variables.The symptom variables included were divided the clinical symptoms and signs of stable COPD into three categories by R-type hierarchical clustering,which more objectively reflected the clinical characteristics of stable COPD.Conclusion:Patients in the stable period of clinical COPD are characterized by coexistence of deficiency and excess,mixed with cold and heat,which shows the functional characteristics of multiple viscera deficiency in the core of the lung and spleen.

Chronic obstructive pulmonary disease(COPD)Stable periodMultiple viscera deficiency in the core of the lung and spleenFunctional characteristics of zang-fu organsFactor analysisCluster analysis

李磊、李友林、李春雷、吴东良、李尚点、马文静、史琦、阎玥

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北京中医药大学东直门医院,北京 100700

中日友好医院中医肺病二部,国家中医药管理局重点研究室(肺病慢性咳喘),中医药防治过敏性疾病北京市重点实验室(BZ0321),中日友好医院呼吸中心,国家呼吸疾病临床研究中心,北京 100029

北京中医药大学,北京 100029

慢性阻塞性肺疾病 稳定期 肺脾核心两本多脏虚 脏腑功能特征 因子分析 聚类分析

国家自然科学基金青年科学基金中央财政转移支付地方项目

81904184

2024

中华中医药杂志
中华中医药学会

中华中医药杂志

CSTPCD北大核心
影响因子：1.135
ISSN：1673-1727
年,卷(期)：2024.39(4)
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