首页|支气管扩张症合并亚临床动脉硬化性疾病患者的临床特征与高危因素相关性分析及中医证型分布研究

支气管扩张症合并亚临床动脉硬化性疾病患者的临床特征与高危因素相关性分析及中医证型分布研究

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目的:分析支气管扩张症(以下简称支扩)合并亚临床动脉硬化性疾病(SAS)患者的高危因素及中医证型分布规律.方法:采用回顾性横断面调查研究方法,选取2021年7月至2022年8月因急性加重就诊于江西中医药大学附属医院的支扩患者157例,根据合并SAS与否分为支扩合并SAS组(91例)和单纯支扩组(66例).描述两组在一般资料方面的特征,用倾向得分匹配法消除组间混杂因素,Logistic回归模型分析支扩合并SAS的影响因素,并进行中医证型分布规律的探讨.结果:在控制其他因素的条件下,FEV1％pred、FVC％pred、CD4+T、CD8+T可以显著影响支扩合并SAS的发病,为影响支扩合并SAS发病的高危因素.单纯支扩组以实证为主,痰热蕴肺证最常见,占比51.52％(34/66);支扩合并SAS组以虚实夹杂证为主,痰热阻肺兼气阴两虚证最常见,占比42.42％(28/66).结论:肺通气功能的下降与机体免疫机能的减弱为支扩合并SAS发病的独立危险因素;与单纯支扩相比,支扩合并SAS患者的中医证型更多呈现虚实夹杂的病机特点,痰热阻肺兼气阴两虚证最常见.
Correlation analysis of clinical characteristics and high risk factors in patients with bronchiectasis with subclinical arteriosclerotic disease and distribution of traditional Chinese medicine syndrome types
Objective:To analyze the high risk factors and the distribution of traditional Chinese medicine(TCM)syndrome types in patients with bronchiectasis with subclinical arteriosclerotic disease(SAS).Methods:A retrospective cross-sectional study was conducted,a total of 157 patients with bronchiectasis who were admitted to The Affiliated Hospital of Jiangxi University of Chinese Medicine due to acute exacerbation from July 2021 to August 2022 were selected.According to whether they had SAS or not,they were divided into the bronchiectasis with SAS group(91 cases)and the simple bronchiectasis group(66 cases).Propensity score matching method was used to eliminate confounding factors between groups.Logistic regression analysis was used to analyze the influencing factors of bronchiectasis with SAS,and the distribution of TCM syndrome types was discussed.Results:FEV1％pred,FVC％pred,CD4T and CD8+T could significantly affect the incidence of bronchiectasis combined with SAS,which were the high risk factors affecting the incidence of bronchiectasis with SAS.The simple bronchiectasis group was mainly based on empirical evidence,and the syndrome of phlegm-heat accumulation in the lung was the most common,accounting for 51.52％(34/66).The bronchiectasis with SAS group was mainly characterized by deficiency and excess syndrome,and the most common syndrome was phum-heat obstruction and deficiency of both lung qi and yin,accounting for 42.42％(28/66).Conclusion:The decrease of pulmonary ventilation function and immune function are independent risk factors for bronchiectasis with SAS.Compared with bronchiectasis alone,the TCM syndrome types of bronchiectasis with SAS are more characterized by the combination of deficiency and excess,and the syndrome of phum-heat obstruction and deficiency of qi and yin is the most common.

BronchiectasisAcute exacerbationSubclinical arteriosclerotic diseaseHigh risk factorsTraditional Chinese medicine syndrome types

尹宝婷、余建玮、李陶、黄帅亮、周妮

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江西中医药大学,南昌 330004

江西中医药大学附属医院,南昌 330006

支气管扩张症 急性加重期 亚临床动脉硬化性疾病 高危因素 中医证型

国医大师洪广祥师承工作室江西省中医药中青年骨干人才项目江西中医药大学校级研究生创新专项

赣中医药科教字[2020]2号JZYC22S44

2024

中华中医药杂志
中华中医药学会

中华中医药杂志

CSTPCD北大核心
影响因子：1.135
ISSN：1673-1727
年,卷(期)：2024.39(4)
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