茵芩清肺颗粒联合西医常规疗法治疗儿童重症肺炎支原体肺炎湿毒闭肺证的临床疗效观察
Clinical observation on the therapeutic effect of Yinqin Qingfei Granules combined with conventional western medicine therapy in the treatment of severe Mycoplasma pneumoniae pneumonia in children with damp-toxin blocking lung syndrome
宋哲 1贾广媛 2王晓 2张葆青2
作者信息
- 1. 山东中医药大学第一临床医学院,济南 250355;山东中医药大学附属医院儿科,济南 250011
- 2. 山东中医药大学附属医院儿科,济南 250011
- 折叠
摘要
目的:评价茵芩清肺颗粒治疗儿童重症肺炎支原体肺炎(SMPP)湿毒闭肺证的临床疗效.方法:选取2021年1月—2022年12月于山东省内6家三甲医院确诊的120例湿毒闭肺型SMPP患儿作为研究对象.对照组(60例)采取西医常规治疗方案,治疗组(60例)在此基础上加予茵芩清肺颗粒口服,疗程7d.从疾病总有效率、主要症状改善情况、实验室指标及其他治疗手段(糖皮质激素、人免疫球蛋白、支气管镜介入)应用频次等方面评价茵芩清肺颗粒的临床疗效.结果:治疗组总有效率98.33％,高于对照组的91.67％(P＜0.05).与对照组比较,治疗组患儿退热时间和咳嗽缓解时间显著缩短(P＜0.01).治疗后两组患儿的C-反应蛋白(CRP)、中性粒细胞淋巴细胞比值(NLR)、降钙素原(PCT)、乳酸脱氢酶(LDH)、D-二聚体(D-D)水平较本组治疗前显著降低(P＜0.01),治疗后,治疗组在降低PCT、LDH、D-D方面显著优于对照组(P＜0.01).治疗组糖皮质激素、人免疫球蛋白和支气管镜介入的使用次数显著低于对照组(P＜0.05).两组患儿均未发生明显不良事件.结论:茵芩清肺颗粒联合西医常规治疗可显著改善SMPP患儿的临床症状,抑制机体炎症反应,纠正凝血功能异常.茵芩清肺颗粒临床应用安全有效,值得推广.
Abstract
Objective:To evaluate the clinical efficacy of Yinqin Qingfei Granules in the treatment of severe Mycoplasma pneumoniae pneumonia(SMPP)in children with damp-toxin blocking lung syndrome.Methods:A total of 120 children with SMPP(damp-toxin blocking lung syndrome)diagnosed in six tertiary hospitals in Shandong Province from January 2021 to December 2022 were selected as the research subjects.The treatment group(60 cases)was treated with Yinqin Qingfei Granules combined with conventional western medicine.The control group(60 cases)only received conventional western medicine treatment.The treatment period was all one week.The clinical efficacy of Yinqin Qingfei Granules was evaluated from the perspectives of the overall effective rate,improvement of main symptoms,laboratory indicators,and frequency of other treatments such as glucocorticoids,human immunoglobulins,and bronchoscopy intervention.Results:The total effective rate of the treatment group was 98.33％,which was significantly higher than that of the control group(91.67％,P＜0.05).Compared with the control group,the treatment group significantly shortened the time for fever relief and cough relief(P＜0.01).After treatment,the levels of C-reactive protein(CRP),neutrophil lymphocyte ratio(NLR),procalcitonin(PCT),lactate dehydrogenase(LDH)and D-dimer(D-D)in the two groups of children significantly decreased compared to before treatment(P＜0.01).After the treatment,the treatment group was significantly superior to the control group in reducing PCT,LDH,and D-D(P＜0.01).The frequency of use of glucocorticoids,human immunoglobulin,and bronchoscopy intervention was significantly lower in the treatment group than in the control group(P＜0.05).There were no significant adverse events in both groups of children.Conclusion:Yinqin Qingfei Granules combined with conventional western medicine treatment can significantly improve the clinical symptoms of children with SMPP,inhibit inflammatory response,and correct coagulation abnormalities.The clinical application of Yinqin Qingfei Granules is safe and effective and worthy of promotion.
关键词
茵芩清肺颗粒/重症肺炎支原体肺炎/儿童/湿毒闭肺/临床疗效Key words
Yinqin Qingfei Granules/Severe Mycoplasma pneumoniae pneumonia(SMPP)/Children/Damp-toxin blocking lung syndrome/Clinical efficacy引用本文复制引用
基金项目
山东省中西医结合专病防治项目(YXH2019ZXY010)
山东省中医药科技发展计划(2021M172)
出版年
2024
NETL
NSTL
万方数据