According to Huangdi Neijing,nutrient-defense is the pivot of human's sleep.The circulation pattern of nutrient'travels in the yang during the day and in the yin at night'lays down the premise of nutrient-defense in charge of sleep and awakening.Lingshu·Yingwei Shenghui recorded that qi-blood disharmony,nutrient-qi decline and defense-qi aggression are the main causes of sleeplessness in the elderly.The authors believe that nutrient-defense disharmony in the elderly is mainly closely related to the five aspects of qi-blood disharmony,deficiency of yin fluid,deficiency of yang qi,internal obstruction of static blood and spleen-stomach disharmony.Therefore,this paper explains the mechanism of sleeplessness in the elderly by discussing the relationship between the five aspects mentioned above and nutrient-defense disharmony.This study provides ideas for future studies of sleep characteristics in the elderly and improvement of sleep quality in the elderly.