Analysis of the characteristics of acute kidney injury animal models based on the clinical characteristics of traditional Chinese and Western medicine
Based on the characteristics of the etiology,pathogenesis and clinical symptoms of acute kidney injury in traditional Chinese and Western medicine,this paper organizes the existing books and literature to obtain clinical diagnosis standards,analyzes the existing animal models of acute kidney injury,evaluates the consistency between the model and clinical manifestations,and summarizes the advantages and disadvantages.It is found that the cisplatin injection method has a high degree of anastomosis,and the model modeling method is simple and feasible,which can reflect some indicators of clinical diagnosis of Western medicine,and to a certain extent,reflect the clinical manifestations of traditional Chinese medicine,but it lacks the differentiation of traditional Chinese medicine syndromes.Overall analysis of the existing acute kidney injury modeling methods,found that the current diagnostic standards are mainly Western medicine detection indicators,lacking TCM syndrome model,and the macroscopic performance of animals has certain differences,which can not accurately reflect the pathological process of the disease.It can improve the accuracy of model evaluation to a certain extent by formulating relevant behavioral scales.On the basis of the existing model,the pathogenic factors of traditional Chinese medicine can be added to reflect the combination of traditional Chinese medicine disease symptoms and animal models,so that the animal model can better reflect the clinical performance of AKI traditional Chinese medicine,and better establish an animal model that meets the diagnostic standards of traditional Chinese and western medicine.
Acute kidney injuryGuangeDribbling and retention of urineCharacteristics of the diseaseAnimal modelClincal anastomosis
NETL
NSTL
万方数据
