Traditional Chinese medicine(TCM)has beneficial effect in the treatment of respiratory diseases.Treatment based on syndrome differentiation is a characteristic of TCM diagnosis and treatment.In order to make the efficacy and mechanism of TCM clear,it is very important to build suitable animal models of combination of disease and syndrome.Based on relevant literature,this article summarized the characteristic of animal models of pneumonia,bronchial asthma,chronic obstructive pulmonary disease and pulmonary fibrosis,and found that the principles of establishing animal models of integrated disease and symptom are basically the same.For example,the animal model of spleen deficiency syndrome is based on the principle of poor diet or disharmony of the spleen and stomach,and the syndrome of cold fluid in the lung is based on cold stimulation.However,some problems were found,such as some TCM models were lack of direct TCM theoretical basis and lack of evaluation system for model success.It was also suggested that the model establishment method should be guided by TCM theory,and the evaluation system should combine macroscopic and microscopic aspects,so as to achieve multiple comparisons between disease and syndrome,between syndrome and symptoms,and the effects of intervention,so that the reliability of animal models combining disease and syndrome could be explained.
Combination of disease and syndromePneumoniaBronchial asthmaChronic obstructive pulmonary diseasePulmonary fibrosisAnimal modelRespiratory system
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