With the advent of new clinical drugs such as proteasome inhibitors,immunomodulators and monoclonal antibodies,the survival of patients with multiple myeloma(MM)has been greatly improved.However,MM is still an incurable hematologic tumor,its pathogenesis is still unknown,and it also faces many problems such as difficult treatment and drug resistance.Therefore,some new and more effective treatment methods are still important clinical needs.In recent years,Chinese medicine technology has shown great advantages and potential in promoting multiple myeloma cell apoptosis,inhibiting cell proliferation and invasion,improving the sensitivity of traditional chemotherapy drugs,reversing drug resistance,etc.In particular,the study on the effect of effective chemical components of Chinese medicine has become a hot spot,and relevant studies have been increasing,and the development and application prospects are broad.In this paper,we reviewed the recent years'research progress on the mechanism of action of traditional Chinese medicine(TCM)active components such as turmeric,scutellaria,garcinia,Herba oryzae,Artemisia artemisia and tripterygium wilfordii in the intervention of multiple myeloma,in order to further clarify the mechanism of action of TCM active components against MM and provide a new direction for TCM targeted treatment of MM.
Traditional Chinese medicinePharmacodynamic componentsMultiple myelomaMechanism of actionHematologic tumorResearch progress
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