Cornus officinalis is the dried and mature pulp of cornus officinalis.The chemical active components of cornus officinalis mainly include iridoid glycosides,tannins,flavonoids,triterpenoids,organic acids and their esters,and polysaccharides.With the in-depth study of its pharmacological effects,Cornus officinalis and its extracts have been confirmed to have the effects of protecting the heart,protecting nerves,anti-oxidation,anti-tumor,anti-aging,anti-inflammatory,analgesic,anti-osteoporosis,anti-amnesia,anti-depression and immune regulation.Studies on the molecular mechanism of the anti-tumor effects of Cornus officinalis and its extracts show that Cornus officinalis and its extracts can induce apoptosis of tumor cells,inhibit proliferation of tumor cells,block cell cycle,affect signal pathway,regulate immunity and so on.In this review,the anti-tumor mechanism of Cornus officinalis and its extracts is summarized,in order to provide theoretical basis for the anti-tumor treatment of Cornus officinalis and its extracts.
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