The disorder of glycolipid metabolism is the core pathological mechanism of many metabolic diseases.The incidence rate of its related diseases is increasing year by year,which seriously threatens human life and health.As a traditional and commonly used Chinese medicine,Poligonati Rhizoma has the effects of nourishing yin and moistening the lungs,invigorating the spleen and replenishing qi,nourishing the kidney and filling essence.The main chemical components of Poligonati Rhizoma are polysaccharides,saponins and flavonoids,which can prevent and treat diseases related to glycolipid metabolism disorders through multiple pathways and targets,such as reducing insulin resistance,regulating intestinal flora structure,enhancing immune cell activity,and improving mitochondrial function.This article systematically reviews the pharmacological effects and mechanisms of traditional Chinese medicine Poligonati Rhizoma in the treatment of diseases related to glycolipid metabolism disorders,in order to provide theoretical basis for the development of its functional drugs.