Objective:To observe and study the influencing factors closely related to the therapeutic effect,such as excipients,concoctions and cooling measures,which are not detailed in the current standard of cake separated moxibustion.Methods:Different proportions of excipients and powder were mixed to make medicine cake,and the characteristics of medicine cake were compared;Under the same other conditions,the temperature changes in the process of moxibustion were recorded with a temperature recorder and the corresponding indicators were compared by using different mixing agents and cooling measures.Results:Excipients should be added in the preparation of drug cake,and the best drug cake was prepared when the ratio of drug powder to excipients was 1∶1;The difference in the total duration of moxibustion application between different blending agents was statistically significant(P<0.01),and there was a significant difference in the highest temperature per Zhuang under different blending agents(P<0.01);Whether or not to take cooling measures has a very significant difference in the duration of temperature between 43 ℃ and 48 ℃(P<0.01).Conclusion:Excipients should be added to the preparation of cake separated moxibustion cake,and the recommended proportion is powder:excipient=1∶1;Ginger juice or yellow rice wine is recommended for the selection of blending agents;In the process of moxibustion,it is suggested to consider adding appropriate cooling measures.