首页|基于真实世界的柴胡加龙牡汤治疗情志病的疗效观察

基于真实世界的柴胡加龙牡汤治疗情志病的疗效观察

Observation on the curative effect of Chaihu plus Longmu Decoction in treating emotional disease based on the real world

扫码查看
目的:基于真实世界观察柴胡加龙牡汤治疗情志病的临床疗效.方法:选取热郁少阳型情志病(抑郁症、焦虑症、失眠症)患者124例,按照患者意愿分为治疗组66例和对照组58例.治疗组予柴胡加龙牡汤加减,对照组根据临床诊疗指南结合患者个体采用相应西药,疗程均为12周.采用倾向评分法将两组患者进行匹配,最终46对匹配成功.比较两组治疗前后HAMD、HAMA、PSQI、中医证候评分并评价疗效.结果:治疗组临床疗效愈显率及中医证候疗效总有效率、愈显率均显著优于对照组(P<0.05,P<0.01).治疗后治疗组HAMD、HAMA、PSQI分值以及中医证候评分较对照组降低更显著(P<0.01,P<0.05),其改善心烦/紧张惊惕、乍寒乍热/形寒身热、胸满闷、口干苦、纳差等症状显著优于对照组(P<0.05,P<0.01).结论:柴胡加龙牡汤治疗情志病疗效确切,可有效减轻抑郁、焦虑、失眠程度,改善热郁少阳证候.
Objective:To observe the clinical effect of Chaihu plus Longmu Decoction in the treatment of emotional diseases based on the real world.Methods:A total of 124 patients with heat-depressed Shaoyang-type emotional diseases(depression,anxiety,insomnia)were selected and divided into treatment group(66 cases)and control group(58 cases)according to their will.The treatment group was treated with Chaihu plus Longmu Decoction,while the control group was treated with the corresponding medicine according to the clinical treatment guidelines combined with individual patients.The course of treatment was 12 weeks.The two groups were matched using propensity score method,and finally 46 pairs were matched successfully.The HAMD,HAMA,PSQI,and TCM syndrome scores of the two groups before and after treatment were compared,and the therapeutic effect was evaluated.Results:The markedly effective rate of the clinical effecacy and the total effective rate and markedly effective rate of TCM syndromes of the treatment group were better than those of the control group(P<0.05,P<0.01).After treatment,the scores of HAMD,HAMA,PSQI and total scores of TCM syndromes in the treatment group were significantly decreased than those in the control group(P<0.01,P<0.05).The treatment group was better than the control group in improving the symptoms of upset,tension,cold and heat disorder,chest fullness,dry and bitter mouth and poor appetite(P<0.05,P<0.01).Conclusion:Chaihu plus Longmu Decoction is effective in the treatment of emotional diseases,which can effectively reduce the degree of depression,anxiety and insomnia,and improve the syndrome of heat-depressed Shaoyang.

Emotional diseaseChaihu plus Longmu DecoctionHeat-depressed ShaoyangReal world studyObservation on curative effect

洑寒莹、戈鑫霞、李雅琦、李思祺、过伟峰

展开 >

南京医科大学附属儿童医院,南京 210008

常熟市第一人民医院,江苏常熟 215501

南京市中西医结合医院,南京 210014

南京中医药大学附属医院,南京 210029

展开 >

情志病 柴胡加龙牡汤 热郁少阳 真实世界研究 疗效观察

江苏省高等学校优势学科建设工程项目

161014

2024

中华中医药杂志
中华中医药学会

中华中医药杂志

CSTPCD北大核心
影响因子:1.135
ISSN:1673-1727
年,卷(期):2024.39(6)
  • 10