Clinical and basic research of regulating endometrial receptivity by Erbu Zhuyu Decoction
With the increasing demand for female fertility and the wide application of assisted reproduction technology,how to regulate endometrial receptivity has become a key issue in the field of reproduction that needs to be resolved urgently.In improving the endometrial receptivity,professor XIAO Chengcong,master of Chinese medicine originally creates the Erbu Zhuyu Decoction,which is designed to'replenish the kidney qi and open the cytosolic veins'.Clinical studies have shown that Erbu Zhuyu Decoction and its improved formula can improve Chinese medicine symptoms and hormone levels,increase endometrial blood flow,improve the endometrial microenvironment,correct the hypercoagulable state of the blood,promote the establishment and stability of the endometrial vascular network,and then regulate the endometrial receptivity.The mechanism of effect covers multiple targets and signalling pathways such as stem cell factor,integrin α V β 3,homobox gene 10,autophagy,angiogenesis,and oxidative stress,which regulate endometrial receptivity through the three links of localisation,adherence,and invasion of the follicle during the process of follicle implantation.We hope to provide theoretical and experimental basis for systematically and scientifically inheriting and developing the academic experience of Yanjing XIAOs'academic school of gynecology,improving the clinical pregnancy rate,and helping traditional Chinese medicine to solve the difficult problems in the field of assisted reproduction.
Erbu Zhuyu DecoctionEndometrial receptivityYanjing XIAOs'gynecologyAssisted reproduction technologyIVF-ETTraditional Chinese medicine
NETL
NSTL
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