Exploration on the potential mechanism of acupuncture in the treatment of neuropathic pain based on the'interferon-gliacyte-central sensitization'pathway
Neuropathic pain(NP)is pain caused by somatosensory neurological lesions or diseases,which is characterized by spontaneous pain,nociceptive hypersensitivity and abnormal pain,and is poorly treated with conventional analgesics.Acupuncture can significantly relieve NP symptoms and improve patients'mood and quality of life with fewer side effects,but its specific mechanism is not clear.Central sensitization is an important part in the development and maintenance of NP,and the activation of glial cells induces'glial cell hyperplasia'and the release of related mediators to induce pain,which is involved in the central sensitization process.Interferon is a class of endogenous cytokines with antiviral,antiproliferative and immunomodulatory properties,which can promote central sensitization and induce pain through glial cell activation.In this paper,we explain the pathogenesis of NP from the'interferon-glia-central sensitization'pathway,and explore the potential biological mechanism of acupuncture in treating NP from the point of view that acupuncture may regulate interferon.
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