泻痢康胶囊介导肠道菌群调控TNFR1/RIP1/Complex Ⅰ信号通路治疗HIV/AIDS腹泻的机制探析
Mechanism analysis of Xielikang Capsule mediated intestinal flora regulating TNFR1/RIP1/Complex Ⅰ signaling pathway in treatment of HIV/AIDS diarrhea
姜琦 1许前磊 2郭会军 1桑锋 1李鹏宇1
作者信息
- 1. 河南中医药大学第一附属医院,郑州 450000
- 2. 河南中医药大学第一附属医院,郑州 450000;河南中医药大学,郑州 450046;河南省病毒性疾病中医药防治重点实验室,郑州 450008
- 折叠
摘要
艾滋病腹泻是艾滋病患者常见的临床并发症,其病程长、缠绵难愈,严重影响了此类患者的工作与生活.艾滋病腹泻的发生与异常分泌的TNF-α激活RIP1/Complex Ⅰ通路、肠黏膜屏障受损,菌群结构失衡相关.泻痢康胶囊能调节TNF-α分泌,修复肠黏膜屏障,调节菌群结构,减少CD4+T淋巴细胞的持续耗损,促进免疫机能修复.文章浅析泻痢康胶囊治疗艾滋病腹泻的作用机制,以期丰富其科学内涵.
Abstract
Diarrhea in AIDS is a prevalent clinical complication among AIDS patients.It has a protracted course,is persistent and refractory to treatment,seriously influencing the work and life of these patients.The occurrence of diarrhea in AIDS is associated with the abnormal secretion of TNF-α activating the RIPl/Complex I pathway,the damaged intestinal mucosal barrier,and the imbalance of flora structure.Xielikang Capsule can regulate the secretion of TNF-α,repair the intestinal mucosal barrier,regulate the flora structure,reduce the continuous depletion of CD4+T lymphocytes,and promote the restoration of immune function.This article explores the mechanism of Xielikang Capsule in treating diarrhea in AIDS to further enrich its scientific connotation,with the anticipation of facilitating the research.
关键词
泻痢康胶囊/艾滋病相关腹泻/肠道菌群/TNFR1/RIP1/Complex/Ⅰ信号通路Key words
Xielikang Capsule/AIDS related diarrhea/Intestinal flora/TNFRl/RIP1/Complex Ⅰ signaling pathway引用本文复制引用
基金项目
国家自然科学基金项目(81873289)
国家自然科学基金项目(82274474)
中原青年拔尖人才项目(ZYYCYU202012153)
河南省中医药科学研究专项(2019JDZX2045)
河南省科技攻关项目(232102311207)
出版年
2024
国家科技期刊平台
NSTL
万方数据